Mrs Samira Bawumia advised against sitting on the fence while the country votes to elect a new president and members of parliament for the next four years.
“Go out and vote peacefully. Let your vote count. Don’t sit on the fence. Change is coming!” she tweeted on election day Wednesday 7 December.
There are seven main candidates in the presidential race including President John Mahama of the governing National Democratic Congress (NDC), who is seeking re-election for a second and final four-year term.
His main contender in the race is Nana Akufo-Addo, who is having a third go at the presidency.
The rest are former First Lady Nana Konadu Agyeman-Rawlings of the National Democratic Party (NDP), Ivor Greenstreet of the Convention People’s Party (CPP), Dr Edward Mahama of the People’s National Convention (PNC), Dr Papa Kwesi Nduom of the Progressive People’s Party (PPP), and independent candidate Jacob Osei Yeboah.
Scores of voters queued up at dawn in anticipation of voting early.
Some voters were seen in queues as early as midnight. Some of them were also holding queue spots for their family members.